Why are T-Cell Engagers the Next Frontier in Autoimmune Therapy?
As the autoimmune drug development landscape evolved, the promise of T-cell engagers (TCEs) was becoming impossible to ignore. Unlike cell therapies, TCEs offer a more cost-effective, off-the-shelf option with easier administration and reduced logistical hurdles making them ideal for treating chronic autoimmune diseases.
In 2025, what began in oncology was then being smartly re-engineered for autoimmunity: optimized CD3 affinities, new strategies to mitigate CRS, and highly selective targeting were paving the way for safer, more durable TCE therapies. But unlocking the full potential of TCEs for autoimmune conditions demanded focused, cross-functional collaboration.
That’s where the T-Cell Engager for Autoimmune Disease Summit came in. This was the only industry meeting solely dedicated to TCEs in autoimmunity bringing together translational scientists, immunology pioneers, and drug development leaders to tackle the specific preclinical, mechanistic, and regulatory hurdles unique to this modality.
Whether you were developing novel formats, exploring new immune targets, or preparing for IND submission, this summit provided the deep technical exchange and curated networking you needed to move forward with confidence.
What to Expect?
Engineering Smarter TCEs
Learning how developers were reducing immune activation while enhancing precision and tissue penetration.
Expanding Target Space
Uncovering novel disease drivers and immune cell populations beyond B cell targets to enable tailored and differentiated therapeutic approaches.
Clinical-Ready Design
Optimizing dosing, antagonism, and safety profiles to align with the unique demands of autoimmune diseases and meet the expectations of rheumatologists and regulators.
Real-World Translation
Gaining practical insights from top biopharma and academic experts leading the charge on IND-enabling studies, preclinical development, and early-stage trials.
Explore the Full Event Guide
- Discover how developers are translating lessons from oncology and CAR-T into smarter, more scalable TCE formats
- Discover cutting-edge approaches to optimize therapeutic selectivity, potency, and tolerability in autoimmune settings
- Learn how preclinical models and translational strategies can build regulatory confidence
- Benchmark your programs against real-world clinical insights
- Hear from academic superstars
Attending Companies Include
Explore the Agenda
Hear the latest industry breakthroughs and gain exclusive insights during our packed agenda, interactive roundtables, and panel discussions.
Partner With Us
Position yourself alongside other leading solution providers to ensure your brand is at the heart of biopharma deals.
Join Biopharma Experts
Be part of the hottest conversations with like-minded attendees spanning all stages of drug development and make critical connections during our dedicated networking sessions.