Neely Mozaffarian
Seminars
Wednesday 15th October 2025
Reprogramming Autoimmunity Through Selective B Cell Depletion with T-Cell Engagers
4:30 pm
- Understanding target expression of BCMA in the context of autoimmune diseases
- Targeting long-lived, autoreactive B cells with OM336 to induce a selective and durable immune reset
- Characterizing immune reconstitution post-depletion to distinguish pathogenic memory B cell recovery from protective naive repopulation
- Understanding dynamics of response to BCMA-targeted therapy vs CD19-targeted therapy
