Jun Wang
Senior Scientific Director GemPharmatech
Seminars
Wednesday 28th October 2026
Developing Predictive Preclinical Models to Improve Translation of Autoimmune T-Cell Engagers from Discovery to First-in-Human Studies
11:30 am
- Building next-generation autoimmune disease models that better capture immune-cell depletion, autoantibody dynamics, and tissue-specific pathology, overcoming the limitations of traditional oncology-focused preclinical systems
- Evaluating the translational relevance of organoids, humanized platforms, and advanced in vitro immune models to improve prediction of efficacy, safety, and cytokine release syndrome risk before clinical development
- Correlating preclinical pharmacology and immune-cell depletion data with emerging clinical outcomes to establish more reliable frameworks for candidate selection and dose optimization
