Engineering Autoregulatory T-Cell Engagers to Preserve T-Cell Fitness, Prevent Exhaustion & Expand the Therapeutic Window in Autoimmune Disease
- Developing autoregulatory T-cell engager architectures designed to modulate T-cell activation dynamics, preserving T-cell fitness and functionality while reducing the risk of excessive immune activation, cytokine release, and treatment-related toxicity
- Investigating how controlled and self-regulating immune engagement strategies can prevent T-cell exhaustion, enhance persistence, and maintain potent immunecell depletion across chronic autoimmune disease settings requiring sustained therapeutic activity
- Leveraging translational immune profiling, functional T-cell assays, and preclinical safety models to optimize therapeutic windows and establish differentiated approaches that balance efficacy, durability, and long-term immune tolerability